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Cardiovascular safety of NSAIDs: epidemiology and pharmacology
Traditional NSAIDs and coxib are not so different after all if gastrointestinal and cardiovascular adverse reactions are considered altogether
Inglese
Traditional NSAIDs and coxib are not so different after all if gastrointestinal and cardiovascular adverse reactions are considered altogether
In order to understand and evaluate the potential risks associated with natural products, Italy since 2002 has activated a surveillance system for adverse reactions to these products, which is coordinated by Istituto Superiore della Sanità (ISS).1 At present the database contains 850 reports of adverse reactions to natural products. From the analysis of this database, 5 cases of hypoglycaemia caused by products containing lipoic acid have emerged (4 women and one man).
Intrahepatic bile ducts breakage
Do try and find someone asserting that information in pharmacovigilance is useless. I am sure you will not be very successful. Nevertheless, there are no clear indications on how and when these instruments for information and communication should be used. Even though the new European Regulation – within the Risk Management Plan - pledges for “educational” activities, you will definitely encounter several difficulties if looking for a more precise idea about what to do – or to expect – in regard to information or communication in pharmacovigilance.
L’Agenzia Italiana del Farmaco, in accordo con l’Agenzia Europea dei
Medicinali (EMA), rende disponibile on line nuove ed importanti
informazioni su casi di fascite necrotizzante segnalati con Avastin (bevacizumab).
L’Agenzia Italiana del Farmaco, rende disponibile on line nuove ed importanti raccomandazioni su come minimizzare il rischio di infezione del circolo sanguigno legata alla somministrazione di Remodulin mediante infusione endovenosa (IV) continua.
L’Agenzia Italiana del Farmaco, in accordo con l’Agenzia Europea dei
Medicinali (EMA), rende disponibile on line nuove ed importanti
informazioni in merito alla restrizione delle indicazioni terapeutiche, alle nuove controindicazioni e avvertenze del ranelato di stronzio.
Risk of serious or life-threatening allergic reaction.
These products should not be administered to patients. If a drug product marketed as sterile has microbial contamination, it potentially places patients at risk of serious infection.
Undeclared tadalafil may interact with nitrates found in some prescription drugs such as nitroglycerin and may lower blood pressure to dangerous levels.
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