Alpha1-proteinase inhibitor (Human)

Wed, 01 Sep 2021 12:24:45 -0400
Indicated for maintenance treatment in adults with severe alpha1-proteinase inhibitor (A1-PI) deficiency (e.g., genotypes PiZZ, PiZ(null), Pi(null,null), PiSZ) and clinical evidence of emphysema. Patients are to be under optimal pharmacologic and non-pharmacologic treatment and show evidence of progressive lung disease (e.g., lower forced expiratory volume per second (FEV1) predicted, lower diffusion capacity, impaired walking capacity or increased number of exacerbations) as evaluated by a healthcare professional experienced in the treatment of A1-PI deficiency.