Sibutramine and its active metabolites substantially increase blood pressure and/or pulse rate in some patients and may present significant health risks including heart attack, arrhythmia, and stroke.
Delay or inability to deliver a shock to a patient in cardiac arrest or pace a patient’s heart whose heartbeat is too slow could result in serious injury and/or death.
Cracked vials may result in a lack of sterility assurance. Use of or exposure to a non-sterile product may be associated with adverse events such as fever, chills, sepsis or invasive systemic infections in patients.
Prescribers advised to consider using other antibiotics in patients with heart disease.
Despite rhabdomyolysis being mostly associated with statins, scientific evidences from literature also support the involvement of antiepileptic drugs, such as phenobarbital and phenytoin.1
Recently, a case of this syndrome was reported in a 27 years old patient under monotherapy of levetiracetam, a drug considered safe and commonly used as anti-epileptic in children.2
In the last 10 years, the term "big data" has become a keyword in many different contexts. Despite being a widespread term, though, it is not always clear what it refers to. The most appropriate definition is the one that breaks it down to the so-called "4 Vs": Volume, Variety, Velocity and Veracity, i.e. a big amount of heterogeneous data that are rapidly analysable and undergo quality checks systematically.1
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